I have been having these problems for a while now and have discovered even ways to recreate the issue at any time and how to fix it temporarily.
Whenever you open Polyphone with a specific audio format that is set on your device, it will not like that and make it so all sound on your device is set to be static. The problem here is that polyphone sees this format and becomes most likely confused.
The audio formats that I have tested are 44100 Hz and 48000 Hz (both on 16 bit and 24 bit).
Polyphone doesn't recreate this problem with 44100 Hz on 16 and 24 bit nor 48000 Hz with 16 bit, but it does happen with 48000 Hz with 24 bit.
I am currently going to only use 48000 Hz 16 bit on my system for now until this issue is fixed. Hope this was descriptive enough.